Oris

Oris, short for Boolean Logic-Based Estimation of Synergy Scores, is a module built on top of Boolevard for computing Bliss-type synergy scores from Boolean model ensembles produced with Gitsbe. Within Trafikk, Oris operates on Celios-calibrated model ensembles to assess the impact of single and combined perturbations defined with Drexpa.

In addition to synergy scoring, Oris can also be used as a generic path-based signal transduction quantifier: it measures the propagation of activity from input nodes to selected output nodes in Boolean models, which can serve as a proxy for cell viability or functional output.

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Developed by M. Fariñas