Gitsbe

Gitsbe — Generic Interactions To Specific Boolean Equations — is a Java-based module that generates cell-line-specific Boolean model ensembles. Starting from a general signalling topology and cell-line-calibrated activity profiles (produced by Celios), Gitsbe uses a genetic algorithm to parameterise logic rules so that the resulting models reproduce observed steady-state behaviour.

Each ensemble captures the diversity of Boolean rule sets compatible with the experimental data and serves as input for downstream perturbation analysis with Oris.

Note

Gitsbe is a Java application maintained as part of the DrugLogics project. Full API documentation is available at druglogics.github.io.

---

Developed by J. Zobolas