Siflex

Siflex — SIgnal FLow EXploration — is a Python package for analysing and visualising drug synergy effects on biological signalling networks and pathways. Siflex processes Oris output from the TRAFIKK pipeline to identify and explore synergistic drug combinations through interactive network and pathway visualisations.

Features

  • Synergy Score Analysis: Calculate node-level, pathway-level, and drug combination synergy scores

  • Interactive Network Explorer: Visualise signalling networks with Cytoscape.js across multiple cancer types

  • Pathway Impact Analysis: Explore KEGG pathway responses to drug combinations

  • Multi-Tissue Support: Compare drug effects across different cancer tissues and cell lines

  • 3+2 Panel Layout: Three independent network panels and two pathway comparison panels

  • Dual Dashboard Mode: Run network and pathway explorers simultaneously on different ports

Developed by M. Fariñas & V. Bermúdez