.. _oris-home:

Oris
=====

**Oris**, short for *Boolean Logic-Based Estimation of Synergy Scores*, is a module built on top of `Boolevard <https://github.com/farinasm/boolevard>`_ for computing Bliss-type synergy scores from Boolean model ensembles produced with Gitsbe. Within Trafikk, Oris operates on :ref:`Celios <celios-home>`-calibrated model ensembles to assess the impact of single and combined perturbations defined with :ref:`Drexpa <drexpa-home>`.

In addition to synergy scoring, Oris can also be used as a generic path-based signal transduction quantifier: it measures the propagation of activity from input nodes to selected output nodes in Boolean models, which can serve as a proxy for cell viability or functional output.


.. toctree::
   :maxdepth: 2
   :hidden:

   Overview <self>
   Helpers <helpers>
   Installation and Usage <installation>
   Initial Conditions <initialconditions>
   Sampling <sampling>
   Modes <orismodes>
   Configuration <configuration>

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   <p style="font-size:0.75rem;color:#999;margin-top:1rem;">Developed by M. Fariñas</p>