TRAFIKK Pipeline

TRAFIKK

Systematic prediction and mechanistic interpretation
of anticancer drug synergies

🧬

Celios

Integrates cell-line omics data to calibrate the base network to specific biological contexts.

Omics integration

🧩

Gitsbe

Generates ensembles of logic-based models via genetic-algorithm parameterisation.

Model ensembles

💊

Drexpa

Maps experimental drug panels to in silico perturbation profiles.

Drug panels

⚡

Oris

Computes viability and synergy scores via signal-propagation analysis.

Synergy scoring

📈

Synco

Benchmarks predictions against experimental synergy data with classification metrics.

Benchmarking

🔎

Siflex

Interactive pathway-level exploration of drug synergy effects on signalling networks.

Visualisation

📄 Citation

Fariñas M.*, Bermúdez V.*, Tsirvouli E., Lippestad K., Zobolas J., Aittokallio T., Lehti K.†, Flobak Å.†
TRAFIKK: systematic prediction and mechanistic interpretation of anticancer drug synergies.
Submitted.

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