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TRAFIKK Pipeline
================

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     <h1>TRAFIKK</h1>
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       Systematic prediction and mechanistic interpretation<br>
       of anticancer drug synergies
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       <span class="card-icon">🧬</span>
       <div class="card-title"><a href="celios/index.html">Celios</a></div>
       <p class="card-desc">Integrates cell-line omics data to calibrate the base network to specific biological contexts.</p>
       <span class="card-tag">Omics integration</span>
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     <div class="module-card">
       <span class="card-icon">🧩</span>
       <div class="card-title"><a href="gitsbe/index.html">Gitsbe</a></div>
       <p class="card-desc">Generates ensembles of logic-based models via genetic-algorithm parameterisation.</p>
       <span class="card-tag">Model ensembles</span>
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     <div class="module-card">
       <span class="card-icon">💊</span>
       <div class="card-title"><a href="drexpa/index.html">Drexpa</a></div>
       <p class="card-desc">Maps experimental drug panels to <em>in silico</em> perturbation profiles.</p>
       <span class="card-tag">Drug panels</span>
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       <span class="card-icon">⚡</span>
       <div class="card-title"><a href="oris/index.html">Oris</a></div>
       <p class="card-desc">Computes viability and synergy scores via signal-propagation analysis.</p>
       <span class="card-tag">Synergy scoring</span>
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     <div class="module-card">
       <span class="card-icon">📈</span>
       <div class="card-title"><a href="synco/index.html">Synco</a></div>
       <p class="card-desc">Benchmarks predictions against experimental synergy data with classification metrics.</p>
       <span class="card-tag">Benchmarking</span>
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       <span class="card-icon">🔎</span>
       <div class="card-title"><a href="siflex/index.html">Siflex</a></div>
       <p class="card-desc">Interactive pathway-level exploration of drug synergy effects on signalling networks.</p>
       <span class="card-tag">Visualisation</span>
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     <div class="cite-label">📄 Citation</div>
     Fariñas M.*, Bermúdez V.*, Tsirvouli E., Lippestad K., Zobolas J., Aittokallio T., Lehti K.†, Flobak Å.†<br>
     <strong>TRAFIKK: systematic prediction and mechanistic interpretation of anticancer drug synergies.</strong><br>
     <em>Submitted.</em>
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   <div class="section-divider"><span>Built with ❤️ at NTNU</span></div>


.. toctree::
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   Home <self>
   celios/index
   gitsbe/index
   drexpa/index
   oris/index
   synco/index
   siflex/index